New publication in "Materials Today Chemistry"

Degradable cationic poly(2-oxazoline) analogues (dPOx) were developed to address the challenges of toxicity and immune activation in non-viral gene delivery. These polymers are derived from poly(ethylene imine) and tailored to include varying amounts of primary amino groups, enhancing biocompatibility while maintaining the ability to bind and deliver nucleic acids.

Our latest research demonstrates that dPOx polymers exhibit low cytotoxicity, excellent hemocompatibility, and do not trigger significant inflammatory responses in human monocytes. Their ability to form stable polyplexes and efficiently deliver nucleic acids positions them as promising candidates for safe, non-viral gene therapy.

The complete article can be found here:
https://www.sciencedirect.com/science/article/abs/pii/S2468519425000394External link

Authors: Michael Streiber, Natalie E. Goppert, Vivien Bachmann, Bianca Schulze, Richard Gläßer, Ilya Anufriev, Patrick Schädel, Ivo Nischang, Christine Weber, Oliver Werz, Ulrich S. Schubert, Anja Traeger